Drug interactions
Aripiprazole + Ziconotide
Severity: Moderate
Aripiprazole and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziconotide given intrathecally commonly causes dizziness, confusion and reduced alertness, and aripiprazole adds sedation of its own. The combination may increase cognitive impairment and somnolence.
What this interaction means in plain words
Aripiprazole and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for excess sedation and cognitive or psychiatric changes, and reduce the dose of the concomitant CNS-active drug if needed. Stop ziconotide promptly if serious neuropsychiatric symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
- Asenapine + Ziconotide Moderate
Frequently asked questions
Can I take Aripiprazole with Ziconotide?
MediHelp rates the interaction as moderate. Aripiprazole and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziconotide given intrathecally commonly causes dizziness, confusion and reduced alertness, and aripiprazole adds sedation of its own. The combination may increase cognitive impairment and somnolence.
How serious is the interaction between Aripiprazole and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and cognitive or psychiatric changes, and reduce the dose of the concomitant CNS-active drug if needed. Stop ziconotide promptly if serious neuropsychiatric symptoms occur.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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