Drug interactions
Cabazitaxel + Efavirenz
Severity: Moderate
Cabazitaxel and Efavirenz: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cabazitaxel is metabolised mainly by CYP3A4, so efavirenz as an inducer is expected to reduce its exposure and possibly its efficacy. The legacy direction of effect is the opposite of what induction predicts.
What this interaction means in plain words
Cabazitaxel and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabazitaxel belongs to Oncology; Efavirenz belongs to Anti Virals.
Why it happens
Efavirenz induction of CYP3A4 increases cabazitaxel clearance.
What to do
Cabazitaxel labeling advises avoiding strong CYP3A inducers where possible. Consider a non-inducing antiretroviral and monitor treatment response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Cabazitaxel
Frequently asked questions
Can I take Cabazitaxel with Efavirenz?
MediHelp rates the interaction as moderate. Cabazitaxel and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cabazitaxel is metabolised mainly by CYP3A4, so efavirenz as an inducer is expected to reduce its exposure and possibly its efficacy. The legacy direction of effect is the opposite of what induction predicts.
How serious is the interaction between Cabazitaxel and Efavirenz?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Cabazitaxel labeling advises avoiding strong CYP3A inducers where possible. Consider a non-inducing antiretroviral and monitor treatment response.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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