Drug interactions
Cabazitaxel + Ketoconazole
Severity: Major
Cabazitaxel and Ketoconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole increases cabazitaxel exposure, raising the risk of neutropenia and other serious toxicity.
What this interaction means in plain words
Cabazitaxel and Ketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cabazitaxel belongs to Oncology; Ketoconazole belongs to Anti Fungals.
Why it happens
Ketoconazole inhibits CYP3A4, the main enzyme eliminating cabazitaxel.
What to do
Avoid strong CYP3A4 inhibitors during cabazitaxel therapy. If unavoidable, consider reducing the cabazitaxel dose by 25% and monitor blood counts closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Cabazitaxel
Frequently asked questions
Can I take Cabazitaxel with Ketoconazole?
MediHelp rates the interaction as major. Cabazitaxel and Ketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketoconazole increases cabazitaxel exposure, raising the risk of neutropenia and other serious toxicity.
How serious is the interaction between Cabazitaxel and Ketoconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong CYP3A4 inhibitors during cabazitaxel therapy. If unavoidable, consider reducing the cabazitaxel dose by 25% and monitor blood counts closely.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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