Drug interactions
Cabazitaxel + Nelfinavir
Severity: Major
Cabazitaxel and Nelfinavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4 and can raise cabazitaxel concentrations. This increases the risk of severe neutropenia and other toxicities.
What this interaction means in plain words
Cabazitaxel and Nelfinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cabazitaxel belongs to Oncology; Nelfinavir belongs to Anti Virals.
Why it happens
Nelfinavir inhibits CYP3A4-mediated cabazitaxel metabolism.
What to do
Avoid concurrent use. If it cannot be avoided, consider reducing the cabazitaxel dose and monitor blood counts closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cabazitaxel
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Cabazitaxel with Nelfinavir?
MediHelp rates the interaction as major. Cabazitaxel and Nelfinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nelfinavir inhibits CYP3A4 and can raise cabazitaxel concentrations. This increases the risk of severe neutropenia and other toxicities.
How serious is the interaction between Cabazitaxel and Nelfinavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. If it cannot be avoided, consider reducing the cabazitaxel dose and monitor blood counts closely.
What other medicines interact with Cabazitaxel?
MediHelp also lists interactions of Cabazitaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Bcg intravesical live. The full list is on the Cabazitaxel page.
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