Drug interactions
Cabazitaxel + Palifermin
Severity: Moderate
Cabazitaxel and Palifermin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin stimulates epithelial cell growth, and giving it close to cytotoxic chemotherapy has worsened the severity and duration of oral mucositis. Cabazitaxel can itself cause mucositis.
What this interaction means in plain words
Cabazitaxel and Palifermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabazitaxel belongs to Oncology; Palifermin belongs to Miscellaneous.
Why it happens
Palifermin-driven proliferation of epithelial cells may increase their sensitivity to cytotoxic chemotherapy.
What to do
Do not give palifermin within 24 hours before, during, or within 24 hours after cabazitaxel infusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cabazitaxel
Other interactions of Palifermin
Frequently asked questions
Can I take Cabazitaxel with Palifermin?
MediHelp rates the interaction as moderate. Cabazitaxel and Palifermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palifermin stimulates epithelial cell growth, and giving it close to cytotoxic chemotherapy has worsened the severity and duration of oral mucositis. Cabazitaxel can itself cause mucositis.
How serious is the interaction between Cabazitaxel and Palifermin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give palifermin within 24 hours before, during, or within 24 hours after cabazitaxel infusion.
What other medicines interact with Cabazitaxel?
MediHelp also lists interactions of Cabazitaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Bcg intravesical live. The full list is on the Cabazitaxel page.
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