Drug interactions
Cabazitaxel + Trastuzumab
Severity: Moderate
Cabazitaxel and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab given with myelosuppressive chemotherapy such as cabazitaxel increases the incidence of neutropenia and febrile neutropenia. Cardiac dysfunction from trastuzumab is an additional concern.
What this interaction means in plain words
Cabazitaxel and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabazitaxel belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive pharmacodynamic myelosuppression; no established pharmacokinetic interaction.
What to do
Monitor neutrophil counts and infection signs, using G-CSF when indicated, and monitor cardiac function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cabazitaxel
Other interactions of Trastuzumab
Frequently asked questions
Can I take Cabazitaxel with Trastuzumab?
MediHelp rates the interaction as moderate. Cabazitaxel and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab given with myelosuppressive chemotherapy such as cabazitaxel increases the incidence of neutropenia and febrile neutropenia. Cardiac dysfunction from trastuzumab is an additional concern.
How serious is the interaction between Cabazitaxel and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and infection signs, using G-CSF when indicated, and monitor cardiac function.
What other medicines interact with Cabazitaxel?
MediHelp also lists interactions of Cabazitaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Bcg intravesical live. The full list is on the Cabazitaxel page.
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