Drug interactions
Cabergoline + Darunavir
Severity: Moderate
Cabergoline and Darunavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 strongly. Cabergoline exposure may increase, with more dopaminergic adverse effects such as hypotension and nausea.
What this interaction means in plain words
Cabergoline and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabergoline belongs to Endocrine; Darunavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated cabergoline metabolism.
What to do
Begin cabergoline at a low dose with slow titration and monitor blood pressure and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cabergoline
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Cabergoline with Darunavir?
MediHelp rates the interaction as moderate. Cabergoline and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 strongly. Cabergoline exposure may increase, with more dopaminergic adverse effects such as hypotension and nausea.
How serious is the interaction between Cabergoline and Darunavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Begin cabergoline at a low dose with slow titration and monitor blood pressure and tolerability.
What other medicines interact with Cabergoline?
MediHelp also lists interactions of Cabergoline with, for example, Benperidol, Chlorpromazine, Clarithromycin. The full list is on the Cabergoline page.
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