Drug interactions
Cabergoline + Ephedrine
Severity: Moderate
Cabergoline and Ephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ephedrine is a sympathomimetic that raises blood pressure through alpha and beta adrenergic stimulation. Cabergoline, an ergot derivative, may contribute vasoconstriction and hypertension, so the combination could produce additive pressor effects. Evidence is mainly theoretical.
What this interaction means in plain words
Cabergoline and Ephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabergoline belongs to Endocrine; Ephedrine belongs to Cardiovascular.
Why it happens
Additive vasoconstriction and pressor effects from adrenergic stimulation and ergoline dopaminergic activity.
What to do
Monitor blood pressure when ephedrine is given to a patient taking cabergoline, and use the lowest effective ephedrine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cabergoline
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Cabergoline with Ephedrine?
MediHelp rates the interaction as moderate. Cabergoline and Ephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ephedrine is a sympathomimetic that raises blood pressure through alpha and beta adrenergic stimulation. Cabergoline, an ergot derivative, may contribute vasoconstriction and hypertension, so the combination could produce additive pressor effects. Evidence is mainly theoretical.
How serious is the interaction between Cabergoline and Ephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when ephedrine is given to a patient taking cabergoline, and use the lowest effective ephedrine dose.
What other medicines interact with Cabergoline?
MediHelp also lists interactions of Cabergoline with, for example, Benperidol, Chlorpromazine, Clarithromycin. The full list is on the Cabergoline page.
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