Drug interactions
Cabergoline + Tipranavir
Severity: Moderate
Cabergoline and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, has mixed CYP3A4 effects but net inhibition may raise cabergoline exposure. Ergot toxicity is the theoretical concern. The interaction is poorly characterized for cabergoline.
What this interaction means in plain words
Cabergoline and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabergoline belongs to Endocrine; Tipranavir belongs to Anti Virals.
Why it happens
Possible inhibition of CYP3A4-mediated metabolism of cabergoline, mainly through ritonavir.
What to do
Use the lowest effective cabergoline dose and monitor blood pressure and for ergotism symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cabergoline
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Cabergoline with Tipranavir?
MediHelp rates the interaction as moderate. Cabergoline and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir, given with ritonavir, has mixed CYP3A4 effects but net inhibition may raise cabergoline exposure. Ergot toxicity is the theoretical concern. The interaction is poorly characterized for cabergoline.
How serious is the interaction between Cabergoline and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective cabergoline dose and monitor blood pressure and for ergotism symptoms.
What other medicines interact with Cabergoline?
MediHelp also lists interactions of Cabergoline with, for example, Benperidol, Chlorpromazine, Clarithromycin. The full list is on the Cabergoline page.
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