Drug interactions
Cabozantinib + Crizotinib
Severity: Moderate
Cabozantinib and Crizotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A4 inhibitor and could increase cabozantinib concentrations, since cabozantinib is a CYP3A4 substrate. This may increase toxicities such as diarrhea, hypertension, hand-foot syndrome and hemorrhage.
What this interaction means in plain words
Cabozantinib and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabozantinib belongs to Oncology; Crizotinib belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4, reducing the metabolic clearance of cabozantinib.
What to do
Monitor for cabozantinib adverse effects such as hypertension, diarrhea and bleeding. Reduce the cabozantinib dose if tolerability worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Crizotinib?
MediHelp rates the interaction as moderate. Cabozantinib and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib is a moderate CYP3A4 inhibitor and could increase cabozantinib concentrations, since cabozantinib is a CYP3A4 substrate. This may increase toxicities such as diarrhea, hypertension, hand-foot syndrome and hemorrhage.
How serious is the interaction between Cabozantinib and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cabozantinib adverse effects such as hypertension, diarrhea and bleeding. Reduce the cabozantinib dose if tolerability worsens.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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