Drug interactions
Cabozantinib + Dronedarone
Severity: Moderate
Cabozantinib and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone may increase cabozantinib exposure through CYP3A4 inhibition. Higher levels could increase diarrhea, hypertension, hand-foot syndrome and other toxicities.
What this interaction means in plain words
Cabozantinib and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabozantinib belongs to Oncology; Dronedarone belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition by dronedarone reduces cabozantinib clearance.
What to do
Monitor for cabozantinib toxicity and reduce the dose if adverse effects occur. Also monitor ECG, since both agents can affect QT.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Dronedarone?
MediHelp rates the interaction as moderate. Cabozantinib and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone may increase cabozantinib exposure through CYP3A4 inhibition. Higher levels could increase diarrhea, hypertension, hand-foot syndrome and other toxicities.
How serious is the interaction between Cabozantinib and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cabozantinib toxicity and reduce the dose if adverse effects occur. Also monitor ECG, since both agents can affect QT.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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