Drug interactions
Cabozantinib + Eslicarbazepine
Severity: Moderate
Cabozantinib and Eslicarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cabozantinib is metabolized by CYP3A4, and strong inducers reduce its exposure. Eslicarbazepine is weaker, but reduced efficacy is possible.
What this interaction means in plain words
Cabozantinib and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabozantinib belongs to Oncology; Eslicarbazepine belongs to Central Nervous System.
Why it happens
Eslicarbazepine induces CYP3A4, increasing cabozantinib metabolism.
What to do
Prefer a non-inducing anticonvulsant and monitor tumor response; dose increases are labeled for strong inducers only.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Eslicarbazepine?
MediHelp rates the interaction as moderate. Cabozantinib and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cabozantinib is metabolized by CYP3A4, and strong inducers reduce its exposure. Eslicarbazepine is weaker, but reduced efficacy is possible.
How serious is the interaction between Cabozantinib and Eslicarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing anticonvulsant and monitor tumor response; dose increases are labeled for strong inducers only.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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