Drug interactions
Cabozantinib + Fluconazole
Severity: Moderate
Cabozantinib and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can increase cabozantinib exposure by inhibiting CYP3A4. Higher levels may worsen diarrhea, hypertension, palmar-plantar erythrodysesthesia, hepatotoxicity and other toxicities.
What this interaction means in plain words
Cabozantinib and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabozantinib belongs to Oncology; Fluconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated cabozantinib metabolism by fluconazole.
What to do
Monitor for cabozantinib adverse effects, including blood pressure, liver tests and diarrhea. Interrupt or reduce the cabozantinib dose if toxicity occurs, or choose a non-inhibiting antifungal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Fluconazole?
MediHelp rates the interaction as moderate. Cabozantinib and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole can increase cabozantinib exposure by inhibiting CYP3A4. Higher levels may worsen diarrhea, hypertension, palmar-plantar erythrodysesthesia, hepatotoxicity and other toxicities.
How serious is the interaction between Cabozantinib and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cabozantinib adverse effects, including blood pressure, liver tests and diarrhea. Interrupt or reduce the cabozantinib dose if toxicity occurs, or choose a non-inhibiting antifungal.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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