Drug interactions
Cabozantinib + Furosemide
Severity: Minor
Cabozantinib and Furosemide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide may inhibit MRP2 and thereby raise cabozantinib exposure in theory. Evidence of clinically relevant effect is limited.
What this interaction means in plain words
Cabozantinib and Furosemide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cabozantinib belongs to Oncology; Furosemide belongs to Cardiovascular.
Why it happens
Possible inhibition of MRP2-mediated efflux of cabozantinib.
What to do
Monitor for cabozantinib adverse effects such as diarrhea, hypertension and hand-foot syndrome, and reduce dose per label if toxicity occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Furosemide?
MediHelp rates the interaction as minor. Cabozantinib and Furosemide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Furosemide may inhibit MRP2 and thereby raise cabozantinib exposure in theory. Evidence of clinically relevant effect is limited.
How serious is the interaction between Cabozantinib and Furosemide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cabozantinib adverse effects such as diarrhea, hypertension and hand-foot syndrome, and reduce dose per label if toxicity occurs.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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