Drug interactions
Cabozantinib + Haloperidol
Severity: Moderate
Cabozantinib and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and haloperidol is a weak CYP3A4 inhibitor that is unlikely to raise cabozantinib levels meaningfully. The main concern is additive QT prolongation and arrhythmia risk.
What this interaction means in plain words
Cabozantinib and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabozantinib belongs to Oncology; Haloperidol belongs to Central Nervous System.
Why it happens
Additive QT prolongation; CYP3A4 inhibition by haloperidol is weak.
What to do
Obtain a baseline ECG and monitor ECG, potassium and magnesium during combined use. Correct electrolyte abnormalities and avoid other QT-prolonging agents.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Haloperidol?
MediHelp rates the interaction as moderate. Cabozantinib and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and haloperidol is a weak CYP3A4 inhibitor that is unlikely to raise cabozantinib levels meaningfully. The main concern is additive QT prolongation and arrhythmia risk.
How serious is the interaction between Cabozantinib and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor ECG, potassium and magnesium during combined use. Correct electrolyte abnormalities and avoid other QT-prolonging agents.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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