Drug interactions
Cabozantinib + Ribociclib
Severity: Moderate
Cabozantinib and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cabozantinib is a CYP3A4 substrate, so ribociclib may raise its exposure. This may increase diarrhea, hypertension, hand-foot syndrome and bleeding, and both drugs can also affect QT.
What this interaction means in plain words
Cabozantinib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabozantinib belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing cabozantinib clearance.
What to do
Monitor for cabozantinib toxicity and reduce the dose if adverse effects develop. Check ECG and electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Ribociclib?
MediHelp rates the interaction as moderate. Cabozantinib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cabozantinib is a CYP3A4 substrate, so ribociclib may raise its exposure. This may increase diarrhea, hypertension, hand-foot syndrome and bleeding, and both drugs can also affect QT.
How serious is the interaction between Cabozantinib and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cabozantinib toxicity and reduce the dose if adverse effects develop. Check ECG and electrolytes.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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