Drug interactions
Caffeine + Desogestrel-ethinyl estradiol
Severity: Minor
Caffeine and Desogestrel-ethinyl estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral contraceptives containing ethinyl estradiol slow caffeine clearance, prolonging its half-life. Users may feel more jitteriness, palpitations, or insomnia at usual caffeine intake.
What this interaction means in plain words
Caffeine and Desogestrel-ethinyl estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Caffeine belongs to Miscellaneous; Desogestrel-ethinyl estradiol belongs to Endocrine.
Why it happens
Inhibition of CYP1A2-mediated caffeine metabolism by ethinyl estradiol.
What to do
Advise patients to reduce caffeine intake if they develop jitteriness, tachycardia, or sleep disturbance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Frequently asked questions
Can I take Caffeine with Desogestrel-ethinyl estradiol?
MediHelp rates the interaction as minor. Caffeine and Desogestrel-ethinyl estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral contraceptives containing ethinyl estradiol slow caffeine clearance, prolonging its half-life. Users may feel more jitteriness, palpitations, or insomnia at usual caffeine intake.
How serious is the interaction between Caffeine and Desogestrel-ethinyl estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to reduce caffeine intake if they develop jitteriness, tachycardia, or sleep disturbance.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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