Drug interactions
Caffeine + Morphine
Severity: Minor
Caffeine and Morphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Caffeine may partly counter opioid drowsiness, and it is sometimes used as an analgesic adjuvant. It does not reverse opioid respiratory depression, and no important harmful interaction is expected.
What this interaction means in plain words
Caffeine and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Caffeine belongs to Miscellaneous; Morphine belongs to Musculoskeletal.
Why it happens
Opposing CNS effects from adenosine receptor antagonism by caffeine versus opioid-induced sedation.
What to do
No adjustment is needed; continue routine monitoring of sedation and respiratory status with morphine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Frequently asked questions
Can I take Caffeine with Morphine?
MediHelp rates the interaction as minor. Caffeine and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Caffeine may partly counter opioid drowsiness, and it is sometimes used as an analgesic adjuvant. It does not reverse opioid respiratory depression, and no important harmful interaction is expected.
How serious is the interaction between Caffeine and Morphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed; continue routine monitoring of sedation and respiratory status with morphine.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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