Drug interactions
Calcitriol + Danazol
Severity: Minor
Calcitriol and Danazol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak CYP3A4 inhibitor, and calcitriol is partly cleared through CYP3A4-mediated hydroxylation, so calcitriol exposure could rise slightly. A clinically important effect has not been demonstrated.
What this interaction means in plain words
Calcitriol and Danazol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak inhibition of CYP3A4-mediated calcitriol catabolism by danazol.
What to do
No routine adjustment is needed; check serum calcium if hypercalcemia symptoms develop or when either drug is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcitriol
- Amlodipine-hydrochlorothiazide-valsartan + Calcitriol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcitriol Moderate
- Amobarbital + Calcitriol Moderate
- Apalutamide + Calcitriol Moderate
- Atazanavir + Calcitriol Moderate
- Atenolol-chlorthalidone + Calcitriol Moderate
Frequently asked questions
Can I take Calcitriol with Danazol?
MediHelp rates the interaction as minor. Calcitriol and Danazol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a weak CYP3A4 inhibitor, and calcitriol is partly cleared through CYP3A4-mediated hydroxylation, so calcitriol exposure could rise slightly. A clinically important effect has not been demonstrated.
How serious is the interaction between Calcitriol and Danazol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; check serum calcium if hypercalcemia symptoms develop or when either drug is started or stopped.
What other medicines interact with Calcitriol?
MediHelp also lists interactions of Calcitriol with, for example, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide, Amobarbital. The full list is on the Calcitriol page.
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