Drug interactions
Amobarbital + Calcitriol
Severity: Moderate
Amobarbital and Calcitriol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and can accelerate the breakdown of vitamin D compounds. This may lower calcitriol exposure and reduce its effect on calcium levels.
What this interaction means in plain words
Amobarbital and Calcitriol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Calcitriol belongs to Musculoskeletal.
Why it happens
Amobarbital induces CYP enzymes including CYP3A4, increasing calcitriol catabolism.
What to do
Monitor serum calcium and PTH after starting or stopping the barbiturate. Increase the calcitriol dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcitriol
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Calcitriol?
MediHelp rates the interaction as moderate. Amobarbital and Calcitriol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic enzymes and can accelerate the breakdown of vitamin D compounds. This may lower calcitriol exposure and reduce its effect on calcium levels.
How serious is the interaction between Amobarbital and Calcitriol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and PTH after starting or stopping the barbiturate. Increase the calcitriol dose if needed.
What other medicines interact with Calcitriol?
MediHelp also lists interactions of Calcitriol with, for example, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide, Apalutamide. The full list is on the Calcitriol page.
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