Drug interactions
Atazanavir + Calcitriol
Severity: Moderate
Atazanavir and Calcitriol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir- or cobicistat-boosted or unboosted atazanavir inhibits CYP3A4, which may modestly slow calcitriol clearance. The clinical effect is likely small, but raised calcitriol could cause hypercalcemia.
What this interaction means in plain words
Atazanavir and Calcitriol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Calcitriol belongs to Musculoskeletal.
Why it happens
CYP3A4 inhibition may reduce calcitriol metabolism and raise its exposure.
What to do
Monitor serum calcium and phosphate during co-therapy and reduce the calcitriol dose if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcitriol
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Calcitriol?
MediHelp rates the interaction as moderate. Atazanavir and Calcitriol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir- or cobicistat-boosted or unboosted atazanavir inhibits CYP3A4, which may modestly slow calcitriol clearance. The clinical effect is likely small, but raised calcitriol could cause hypercalcemia.
How serious is the interaction between Atazanavir and Calcitriol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and phosphate during co-therapy and reduce the calcitriol dose if hypercalcemia develops.
What other medicines interact with Calcitriol?
MediHelp also lists interactions of Calcitriol with, for example, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide, Amobarbital. The full list is on the Calcitriol page.
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