Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Calcitriol
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Calcitriol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides reduce urinary calcium excretion and calcitriol increases calcium absorption, so together they can cause hypercalcemia. The risk is highest with oral or high-dose calcitriol and in renal impairment, while topical use carries little systemic exposure.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Calcitriol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Calcitriol belongs to Musculoskeletal.
Why it happens
Additive increases in serum calcium through reduced renal calcium excretion (thiazide) and enhanced intestinal absorption (calcitriol).
What to do
Monitor serum calcium regularly during oral or injectable calcitriol therapy, and reduce the calcitriol dose or review the thiazide if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Calcitriol
- Amlodipine-olmesartan-hydrochlorothiazide + Calcitriol Moderate
- Amobarbital + Calcitriol Moderate
- Apalutamide + Calcitriol Moderate
- Atazanavir + Calcitriol Moderate
- Atenolol-chlorthalidone + Calcitriol Moderate
- Azilsartan-chlorthalidone + Calcitriol Moderate
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Calcitriol?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Calcitriol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides reduce urinary calcium excretion and calcitriol increases calcium absorption, so together they can cause hypercalcemia. The risk is highest with oral or high-dose calcitriol and in renal impairment, while topical use carries little systemic exposure.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Calcitriol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium regularly during oral or injectable calcitriol therapy, and reduce the calcitriol dose or review the thiazide if hypercalcemia develops.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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