Drug interactions
Calcitriol + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Moderate
Calcitriol and Elvitegravir / cobicistat / emtricitabine / tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP3A4 and may raise calcitriol exposure, increasing the risk of hypercalcemia and hypercalciuria. This is a theoretical concern, as calcitriol is cleared mainly by CYP24A1 and also CYP3A4 to some extent. It is not a labeled contraindication.
What this interaction means in plain words
Calcitriol and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP3A4, potentially reducing calcitriol metabolism.
What to do
Monitor serum calcium, phosphate and PTH after starting or stopping the combination. Lower the calcitriol dose if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcitriol
- Amlodipine-hydrochlorothiazide-valsartan + Calcitriol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcitriol Moderate
- Amobarbital + Calcitriol Moderate
- Apalutamide + Calcitriol Moderate
- Atazanavir + Calcitriol Moderate
- Atenolol-chlorthalidone + Calcitriol Moderate
Frequently asked questions
Can I take Calcitriol with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as moderate. Calcitriol and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat inhibits CYP3A4 and may raise calcitriol exposure, increasing the risk of hypercalcemia and hypercalciuria. This is a theoretical concern, as calcitriol is cleared mainly by CYP24A1 and also CYP3A4 to some extent. It is not a labeled contraindication.
How serious is the interaction between Calcitriol and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium, phosphate and PTH after starting or stopping the combination. Lower the calcitriol dose if hypercalcemia develops.
What other medicines interact with Calcitriol?
MediHelp also lists interactions of Calcitriol with, for example, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide, Amobarbital. The full list is on the Calcitriol page.
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