Drug interactions
Calcitriol + Hydrochlorothiazide-olmesartan
Severity: Moderate
Calcitriol and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides reduce urinary calcium excretion, and calcitriol increases calcium absorption, so hypercalcemia may occur. Risk is higher with oral calcitriol or high doses and in renal impairment.
What this interaction means in plain words
Calcitriol and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcitriol belongs to Musculoskeletal; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Additive increase in serum calcium through reduced renal calcium excretion and increased intestinal absorption.
What to do
Monitor serum calcium and renal function periodically. Reduce calcitriol dose or stop thiazide if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Calcitriol
- Amlodipine-hydrochlorothiazide-valsartan + Calcitriol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcitriol Moderate
- Amobarbital + Calcitriol Moderate
- Apalutamide + Calcitriol Moderate
- Atazanavir + Calcitriol Moderate
- Atenolol-chlorthalidone + Calcitriol Moderate
Frequently asked questions
Can I take Calcitriol with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Calcitriol and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides reduce urinary calcium excretion, and calcitriol increases calcium absorption, so hypercalcemia may occur. Risk is higher with oral calcitriol or high doses and in renal impairment.
How serious is the interaction between Calcitriol and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and renal function periodically. Reduce calcitriol dose or stop thiazide if hypercalcemia develops.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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