Drug interactions
Calcitriol + Indinavir
Severity: Moderate
Calcitriol and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4, an enzyme involved in calcitriol inactivation. Higher calcitriol levels could cause hypercalcemia, and indinavir itself carries a risk of kidney stones.
What this interaction means in plain words
Calcitriol and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated catabolism of calcitriol by indinavir.
What to do
Monitor serum calcium and renal function, and lower the calcitriol dose if calcium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcitriol
- Amlodipine-hydrochlorothiazide-valsartan + Calcitriol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcitriol Moderate
- Amobarbital + Calcitriol Moderate
- Apalutamide + Calcitriol Moderate
- Atazanavir + Calcitriol Moderate
- Atenolol-chlorthalidone + Calcitriol Moderate
Frequently asked questions
Can I take Calcitriol with Indinavir?
MediHelp rates the interaction as moderate. Calcitriol and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4, an enzyme involved in calcitriol inactivation. Higher calcitriol levels could cause hypercalcemia, and indinavir itself carries a risk of kidney stones.
How serious is the interaction between Calcitriol and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and renal function, and lower the calcitriol dose if calcium rises.
What other medicines interact with Calcitriol?
MediHelp also lists interactions of Calcitriol with, for example, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide, Amobarbital. The full list is on the Calcitriol page.
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