Drug interactions
Calcitriol + Magnesium supplement
Severity: Moderate
Calcitriol and Magnesium supplement: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcitriol increases intestinal magnesium absorption, so magnesium supplements may lead to hypermagnesemia. Risk is greatest in patients with renal impairment.
What this interaction means in plain words
Calcitriol and Magnesium supplement can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcitriol enhances intestinal absorption of magnesium, adding to the supplemental load.
What to do
Monitor serum magnesium, especially in renal impairment, and reduce or stop the magnesium supplement if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcitriol
- Amlodipine-hydrochlorothiazide-valsartan + Calcitriol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcitriol Moderate
- Amobarbital + Calcitriol Moderate
- Apalutamide + Calcitriol Moderate
- Atazanavir + Calcitriol Moderate
- Atenolol-chlorthalidone + Calcitriol Moderate
Frequently asked questions
Can I take Calcitriol with Magnesium supplement?
MediHelp rates the interaction as moderate. Calcitriol and Magnesium supplement can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcitriol increases intestinal magnesium absorption, so magnesium supplements may lead to hypermagnesemia. Risk is greatest in patients with renal impairment.
How serious is the interaction between Calcitriol and Magnesium supplement?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium, especially in renal impairment, and reduce or stop the magnesium supplement if levels rise.
What other medicines interact with Calcitriol?
MediHelp also lists interactions of Calcitriol with, for example, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide, Amobarbital. The full list is on the Calcitriol page.
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