Drug interactions
Calcitriol + Nafcillin
Severity: Minor
Calcitriol and Nafcillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin may induce CYP3A4 and reduce calcitriol effect. The clinical impact is expected to be small and is mainly relevant during prolonged therapy.
What this interaction means in plain words
Calcitriol and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP3A4 induction by nafcillin raising calcitriol clearance.
What to do
Monitor serum calcium if the combination continues for prolonged therapy, and adjust the calcitriol dose accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcitriol
- Amlodipine-hydrochlorothiazide-valsartan + Calcitriol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcitriol Moderate
- Amobarbital + Calcitriol Moderate
- Apalutamide + Calcitriol Moderate
- Atazanavir + Calcitriol Moderate
- Atenolol-chlorthalidone + Calcitriol Moderate
Frequently asked questions
Can I take Calcitriol with Nafcillin?
MediHelp rates the interaction as minor. Calcitriol and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nafcillin may induce CYP3A4 and reduce calcitriol effect. The clinical impact is expected to be small and is mainly relevant during prolonged therapy.
How serious is the interaction between Calcitriol and Nafcillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium if the combination continues for prolonged therapy, and adjust the calcitriol dose accordingly.
What other medicines interact with Calcitriol?
MediHelp also lists interactions of Calcitriol with, for example, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide, Amobarbital. The full list is on the Calcitriol page.
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