Drug interactions
Calcium acetate + Deferiprone
Severity: Moderate
Calcium acetate and Deferiprone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferiprone binds polyvalent cations including calcium in the gut. Concurrent oral calcium acetate may reduce deferiprone absorption and its iron-chelating effect.
What this interaction means in plain words
Calcium acetate and Deferiprone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium acetate belongs to Genitourinary; Deferiprone belongs to Miscellaneous.
Why it happens
Chelation of deferiprone by calcium ions in the gastrointestinal lumen reduces absorption.
What to do
Separate doses by at least 4 hours. Monitor serum ferritin for loss of chelation efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deferiprone
- Clozapine + Deferiprone Contraindicated
- Abemaciclib + Deferiprone Major
- Acalabrutinib + Deferiprone Major
- Ado-trastuzumab emtansine + Deferiprone Major
- Ado-trastuzumab + Deferiprone Major
- Aldesleukin + Deferiprone Major
Other interactions of Calcium acetate
Frequently asked questions
Can I take Calcium acetate with Deferiprone?
MediHelp rates the interaction as moderate. Calcium acetate and Deferiprone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferiprone binds polyvalent cations including calcium in the gut. Concurrent oral calcium acetate may reduce deferiprone absorption and its iron-chelating effect.
How serious is the interaction between Calcium acetate and Deferiprone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses by at least 4 hours. Monitor serum ferritin for loss of chelation efficacy.
What other medicines interact with Deferiprone?
MediHelp also lists interactions of Deferiprone with, for example, Clozapine, Abemaciclib, Acalabrutinib. The full list is on the Deferiprone page.
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