Drug interactions
Calcium acetate + Ofloxacin
Severity: Moderate
Calcium acetate and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium acetate, used as a phosphate binder, can chelate oral ofloxacin in the gut and lower its absorption. This may result in subtherapeutic antibiotic levels and treatment failure.
What this interaction means in plain words
Calcium acetate and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium acetate belongs to Genitourinary; Ofloxacin belongs to Anti Bacterial.
Why it happens
Chelation of ofloxacin by divalent calcium cations in the gastrointestinal tract reduces its absorption.
What to do
Give oral ofloxacin at least 2 hours before or at least 2 hours after calcium acetate. Monitor clinical response to the antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Calcium acetate and Ofloxacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Calcium acetate
Frequently asked questions
Can I take Calcium acetate with Ofloxacin?
MediHelp rates the interaction as moderate. Calcium acetate and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium acetate, used as a phosphate binder, can chelate oral ofloxacin in the gut and lower its absorption. This may result in subtherapeutic antibiotic levels and treatment failure.
How serious is the interaction between Calcium acetate and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral ofloxacin at least 2 hours before or at least 2 hours after calcium acetate. Monitor clinical response to the antibiotic.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
