Drug interactions
Calcium + Deferiprone
Severity: Moderate
Calcium and Deferiprone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferiprone can bind polyvalent cations such as calcium in the gut, which may reduce its absorption and effect. Calcium-containing supplements and antacids are the main concern.
What this interaction means in plain words
Calcium and Deferiprone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium belongs to Gastrointestinal Tract; Deferiprone belongs to Miscellaneous.
Why it happens
Chelation of deferiprone by calcium in the gastrointestinal tract reduces absorption.
What to do
Separate deferiprone from calcium-containing products by at least 4 hours. Monitor ferritin to confirm chelation response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Deferiprone
- Clozapine + Deferiprone Contraindicated
- Abemaciclib + Deferiprone Major
- Acalabrutinib + Deferiprone Major
- Ado-trastuzumab emtansine + Deferiprone Major
- Ado-trastuzumab + Deferiprone Major
- Aldesleukin + Deferiprone Major
Frequently asked questions
Can I take Calcium with Deferiprone?
MediHelp rates the interaction as moderate. Calcium and Deferiprone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferiprone can bind polyvalent cations such as calcium in the gut, which may reduce its absorption and effect. Calcium-containing supplements and antacids are the main concern.
How serious is the interaction between Calcium and Deferiprone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate deferiprone from calcium-containing products by at least 4 hours. Monitor ferritin to confirm chelation response.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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