Drug interactions
Calcium + Pazopanib
Severity: Moderate
Calcium and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib absorption falls when gastric pH rises, so calcium carbonate may reduce its exposure and efficacy. Short-acting antacids pose less risk than PPIs or H2 blockers if properly timed.
What this interaction means in plain words
Calcium and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium belongs to Gastrointestinal Tract; Pazopanib belongs to Oncology.
Why it happens
Pazopanib has pH-dependent solubility, so higher gastric pH reduces its dissolution and absorption.
What to do
If an antacid is needed, separate it from pazopanib by several hours, for example pazopanib at least 1 hour before or 2 hours after. Prefer antacids over PPIs or H2 blockers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Calcium with Pazopanib?
MediHelp rates the interaction as moderate. Calcium and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib absorption falls when gastric pH rises, so calcium carbonate may reduce its exposure and efficacy. Short-acting antacids pose less risk than PPIs or H2 blockers if properly timed.
How serious is the interaction between Calcium and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If an antacid is needed, separate it from pazopanib by several hours, for example pazopanib at least 1 hour before or 2 hours after. Prefer antacids over PPIs or H2 blockers.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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