Drug interactions
Calcium + Sotorasib
Severity: Moderate
Calcium and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib solubility falls as gastric pH rises, so acid-reducing agents can lower its exposure and effectiveness in KRAS G12C-mutated cancer.
What this interaction means in plain words
Calcium and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium belongs to Gastrointestinal Tract; Sotorasib belongs to Oncology.
Why it happens
Elevated gastric pH reduces sotorasib dissolution and absorption.
What to do
If an antacid is needed, take sotorasib 4 hours before or 10 hours after the antacid. Avoid proton pump inhibitors and H2 blockers where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Calcium with Sotorasib?
MediHelp rates the interaction as moderate. Calcium and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib solubility falls as gastric pH rises, so acid-reducing agents can lower its exposure and effectiveness in KRAS G12C-mutated cancer.
How serious is the interaction between Calcium and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If an antacid is needed, take sotorasib 4 hours before or 10 hours after the antacid. Avoid proton pump inhibitors and H2 blockers where possible.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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