Drug interactions
Calcium + Strontium ranelate
Severity: Moderate
Calcium and Strontium ranelate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium taken at the same time as strontium ranelate reduces strontium absorption, lowering its bone-protective effect.
What this interaction means in plain words
Calcium and Strontium ranelate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium belongs to Gastrointestinal Tract; Strontium ranelate belongs to Musculoskeletal.
Why it happens
Calcium competes with and complexes strontium in the gastrointestinal tract, reducing its absorption.
What to do
Take strontium ranelate at bedtime at least 2 hours after food and calcium, and take calcium supplements at midday or with meals.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Strontium ranelate
Frequently asked questions
Can I take Calcium with Strontium ranelate?
MediHelp rates the interaction as moderate. Calcium and Strontium ranelate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium taken at the same time as strontium ranelate reduces strontium absorption, lowering its bone-protective effect.
How serious is the interaction between Calcium and Strontium ranelate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take strontium ranelate at bedtime at least 2 hours after food and calcium, and take calcium supplements at midday or with meals.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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