Drug interactions
Calcium carbonate + Cyclopenthiazide
Severity: Moderate
Calcium carbonate and Cyclopenthiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics reduce urinary calcium excretion, so combining them with calcium supplements can raise serum calcium. With large calcium doses or alkali intake, hypercalcemia and metabolic alkalosis can occur.
What this interaction means in plain words
Calcium carbonate and Cyclopenthiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazides enhance distal tubular calcium reabsorption, decreasing renal calcium clearance.
What to do
Monitor serum calcium periodically, especially in patients on high-dose calcium or with renal impairment. Reduce calcium dose if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Calcium carbonate and Cyclopenthiazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Cyclopenthiazide?
MediHelp rates the interaction as moderate. Calcium carbonate and Cyclopenthiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics reduce urinary calcium excretion, so combining them with calcium supplements can raise serum calcium. With large calcium doses or alkali intake, hypercalcemia and metabolic alkalosis can occur.
How serious is the interaction between Calcium carbonate and Cyclopenthiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically, especially in patients on high-dose calcium or with renal impairment. Reduce calcium dose if hypercalcemia develops.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
