Drug interactions
Calcium carbonate + Cyclosporine
Severity: Moderate
Calcium carbonate and Cyclosporine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium carbonate may reduce cyclosporine absorption, risking lower blood concentrations and graft rejection. Evidence is limited and inconsistent, and cyclosporine has a narrow therapeutic index. Separate dosing is a sensible precaution.
What this interaction means in plain words
Calcium carbonate and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible binding or reduced gastrointestinal absorption of cyclosporine by antacid cations; the mechanism is not firmly established.
What to do
Separate doses by at least 2 hours and keep timing consistent. Monitor cyclosporine trough concentrations when starting or stopping regular calcium carbonate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Cyclosporine?
MediHelp rates the interaction as moderate. Calcium carbonate and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium carbonate may reduce cyclosporine absorption, risking lower blood concentrations and graft rejection. Evidence is limited and inconsistent, and cyclosporine has a narrow therapeutic index. Separate dosing is a sensible precaution.
How serious is the interaction between Calcium carbonate and Cyclosporine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses by at least 2 hours and keep timing consistent. Monitor cyclosporine trough concentrations when starting or stopping regular calcium carbonate.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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