Drug interactions
Calcium carbonate + Dabrafenib
Severity: Moderate
Calcium carbonate and Dabrafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib solubility falls as gastric pH rises, so antacids could reduce its absorption. A lower exposure may weaken tumor control, although the clinical significance has not been clearly shown.
What this interaction means in plain words
Calcium carbonate and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Dabrafenib belongs to Oncology.
Why it happens
Elevated gastric pH reduces pH-dependent dissolution and absorption of dabrafenib.
What to do
Separate calcium carbonate from dabrafenib by at least 2 hours. Monitor for loss of treatment response if acid-reducing therapy is used long term.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Calcium carbonate and Dabrafenib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Calcium carbonate
Other interactions of Dabrafenib
Frequently asked questions
Can I take Calcium carbonate with Dabrafenib?
MediHelp rates the interaction as moderate. Calcium carbonate and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib solubility falls as gastric pH rises, so antacids could reduce its absorption. A lower exposure may weaken tumor control, although the clinical significance has not been clearly shown.
How serious is the interaction between Calcium carbonate and Dabrafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate calcium carbonate from dabrafenib by at least 2 hours. Monitor for loss of treatment response if acid-reducing therapy is used long term.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
