Drug interactions
Calcium carbonate + Dextroamphetamine
Severity: Minor
Calcium carbonate and Dextroamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Agents that alkalinize the urine reduce renal elimination of amphetamines, raising levels and prolonging effects. Calcium carbonate has weaker alkalinizing effect than sodium bicarbonate but may contribute at high doses.
What this interaction means in plain words
Calcium carbonate and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcium carbonate belongs to Gastrointestinal Tract; Dextroamphetamine belongs to Central Nervous System.
Why it happens
Urinary alkalinization increases tubular reabsorption of dextroamphetamine, decreasing its renal clearance.
What to do
Monitor for increased stimulant effects such as tachycardia, agitation and insomnia when high-dose antacids are used; adjust dextroamphetamine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcium carbonate
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Calcium carbonate with Dextroamphetamine?
MediHelp rates the interaction as minor. Calcium carbonate and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Agents that alkalinize the urine reduce renal elimination of amphetamines, raising levels and prolonging effects. Calcium carbonate has weaker alkalinizing effect than sodium bicarbonate but may contribute at high doses.
How serious is the interaction between Calcium carbonate and Dextroamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased stimulant effects such as tachycardia, agitation and insomnia when high-dose antacids are used; adjust dextroamphetamine dose if needed.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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