Drug interactions
Calcium carbonate + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Moderate
Calcium carbonate and Elvitegravir / cobicistat / emtricitabine / tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Polyvalent cations in calcium carbonate bind elvitegravir in the gut and lower its absorption. Reduced elvitegravir exposure may lead to virologic failure and resistance.
What this interaction means in plain words
Calcium carbonate and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of elvitegravir by calcium in the gastrointestinal tract reduces its absorption.
What to do
Separate the antacid from the combination tablet by at least 2 hours, in either order. Monitor HIV viral load if separation is not reliably achieved.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as moderate. Calcium carbonate and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Polyvalent cations in calcium carbonate bind elvitegravir in the gut and lower its absorption. Reduced elvitegravir exposure may lead to virologic failure and resistance.
How serious is the interaction between Calcium carbonate and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate the antacid from the combination tablet by at least 2 hours, in either order. Monitor HIV viral load if separation is not reliably achieved.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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