Drug interactions
Calcium carbonate + Elvitegravir
Severity: Moderate
Calcium carbonate and Elvitegravir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids containing calcium lower elvitegravir plasma concentrations. This could reduce antiviral activity and promote virologic failure or resistance.
What this interaction means in plain words
Calcium carbonate and Elvitegravir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcium forms ionic complexes with elvitegravir in the gut, reducing absorption independent of gastric pH.
What to do
Separate elvitegravir and calcium carbonate by at least 2 hours. Monitor viral load if separation is unreliable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Elvitegravir?
MediHelp rates the interaction as moderate. Calcium carbonate and Elvitegravir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids containing calcium lower elvitegravir plasma concentrations. This could reduce antiviral activity and promote virologic failure or resistance.
How serious is the interaction between Calcium carbonate and Elvitegravir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate elvitegravir and calcium carbonate by at least 2 hours. Monitor viral load if separation is unreliable.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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