Drug interactions
Calcium carbonate + Erythromycin ethylsuccinate
Severity: Minor
Calcium carbonate and Erythromycin ethylsuccinate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids may alter erythromycin absorption and the effect is inconsistent. Increased levels have been suggested, but the clinical importance is uncertain.
What this interaction means in plain words
Calcium carbonate and Erythromycin ethylsuccinate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
The mechanism is not established; changes in gastric pH may alter dissolution and absorption of the erythromycin ester.
What to do
No dose change is generally needed. Separating doses by about 2 hours is a reasonable approach if concerned about altered response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Calcium carbonate and Erythromycin ethylsuccinate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Erythromycin ethylsuccinate?
MediHelp rates the interaction as minor. Calcium carbonate and Erythromycin ethylsuccinate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antacids may alter erythromycin absorption and the effect is inconsistent. Increased levels have been suggested, but the clinical importance is uncertain.
How serious is the interaction between Calcium carbonate and Erythromycin ethylsuccinate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Separating doses by about 2 hours is a reasonable approach if concerned about altered response.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
