Drug interactions
Calcium carbonate + Hydrochlorothiazide-olmesartan
Severity: Moderate
Calcium carbonate and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides decrease urinary calcium excretion, so calcium supplements can cause hypercalcemia and, with large doses, metabolic alkalosis (milk-alkali syndrome). Risk is highest with high calcium intake or renal impairment.
What this interaction means in plain words
Calcium carbonate and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Thiazides increase renal calcium reabsorption, adding to calcium load from supplementation.
What to do
Monitor serum calcium, particularly with high-dose supplementation or renal impairment. Reduce calcium dose if hypercalcemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Calcium carbonate and Hydrochlorothiazide-olmesartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Calcium carbonate and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides decrease urinary calcium excretion, so calcium supplements can cause hypercalcemia and, with large doses, metabolic alkalosis (milk-alkali syndrome). Risk is highest with high calcium intake or renal impairment.
How serious is the interaction between Calcium carbonate and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium, particularly with high-dose supplementation or renal impairment. Reduce calcium dose if hypercalcemia occurs.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
