Drug interactions
Calcium carbonate + Indapamide
Severity: Moderate
Calcium carbonate and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide, a thiazide-like diuretic, lowers urinary calcium excretion, so calcium carbonate can contribute to hypercalcemia. Alkalosis may occur with large alkali doses.
What this interaction means in plain words
Calcium carbonate and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Indapamide belongs to Cardiovascular.
Why it happens
Enhanced distal tubular calcium reabsorption adds to calcium supplied by the supplement.
What to do
Monitor serum calcium periodically and reduce calcium supplementation if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Other interactions of Indapamide
Frequently asked questions
Can I take Calcium carbonate with Indapamide?
MediHelp rates the interaction as moderate. Calcium carbonate and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide, a thiazide-like diuretic, lowers urinary calcium excretion, so calcium carbonate can contribute to hypercalcemia. Alkalosis may occur with large alkali doses.
How serious is the interaction between Calcium carbonate and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically and reduce calcium supplementation if levels rise.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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