Drug interactions
Calcium carbonate + Indinavir
Severity: Moderate
Calcium carbonate and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir needs an acidic gastric environment for optimal absorption. Antacids raising gastric pH may reduce indinavir exposure, risking reduced antiviral efficacy.
What this interaction means in plain words
Calcium carbonate and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Increased gastric pH from calcium carbonate decreases indinavir dissolution and absorption.
What to do
Separate indinavir and antacid doses by at least 1 hour, giving indinavir first. Monitor virologic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Indinavir?
MediHelp rates the interaction as moderate. Calcium carbonate and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir needs an acidic gastric environment for optimal absorption. Antacids raising gastric pH may reduce indinavir exposure, risking reduced antiviral efficacy.
How serious is the interaction between Calcium carbonate and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate indinavir and antacid doses by at least 1 hour, giving indinavir first. Monitor virologic response.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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