Drug interactions
Calcium carbonate + Infigratinib
Severity: Moderate
Calcium carbonate and Infigratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Infigratinib solubility is pH-dependent, so antacids may reduce its absorption and exposure. This could diminish antitumor efficacy.
What this interaction means in plain words
Calcium carbonate and Infigratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Raised gastric pH reduces the dissolution and absorption of infigratinib.
What to do
If an antacid is required, give infigratinib 2 hours before or 2 hours after calcium carbonate. Avoid proton pump inhibitors and H2 blockers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Infigratinib?
MediHelp rates the interaction as moderate. Calcium carbonate and Infigratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Infigratinib solubility is pH-dependent, so antacids may reduce its absorption and exposure. This could diminish antitumor efficacy.
How serious is the interaction between Calcium carbonate and Infigratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If an antacid is required, give infigratinib 2 hours before or 2 hours after calcium carbonate. Avoid proton pump inhibitors and H2 blockers.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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