Drug interactions
Calcium carbonate + Ledipasvir / sofosbuvir
Severity: Moderate
Calcium carbonate and Ledipasvir / sofosbuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ledipasvir solubility falls as pH rises, so antacids can lower its absorption. This may reduce the likelihood of hepatitis C cure.
What this interaction means in plain words
Calcium carbonate and Ledipasvir / sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Elevated gastric pH reduces pH-dependent solubility and absorption of ledipasvir.
What to do
Separate the antacid from ledipasvir/sofosbuvir by at least 4 hours. Avoid acid suppressants like PPIs unless dosing is adjusted per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Ledipasvir / sofosbuvir?
MediHelp rates the interaction as moderate. Calcium carbonate and Ledipasvir / sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ledipasvir solubility falls as pH rises, so antacids can lower its absorption. This may reduce the likelihood of hepatitis C cure.
How serious is the interaction between Calcium carbonate and Ledipasvir / sofosbuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate the antacid from ledipasvir/sofosbuvir by at least 4 hours. Avoid acid suppressants like PPIs unless dosing is adjusted per labeling.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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