Drug interactions
Calcium carbonate + Lily of the valley
Severity: Moderate
Calcium carbonate and Lily of the valley: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lily of the valley contains cardiac glycosides, and high serum calcium potentiates glycoside effects and arrhythmia risk. Hypercalcemia from calcium therapy could increase toxicity.
What this interaction means in plain words
Calcium carbonate and Lily of the valley can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Elevated calcium augments the myocardial effects of cardiac glycosides, promoting arrhythmias.
What to do
Avoid lily of the valley products. If used, monitor serum calcium and ECG, and avoid high-dose calcium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Lily of the valley?
MediHelp rates the interaction as moderate. Calcium carbonate and Lily of the valley can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lily of the valley contains cardiac glycosides, and high serum calcium potentiates glycoside effects and arrhythmia risk. Hypercalcemia from calcium therapy could increase toxicity.
How serious is the interaction between Calcium carbonate and Lily of the valley?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid lily of the valley products. If used, monitor serum calcium and ECG, and avoid high-dose calcium.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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