Drug interactions
Calcium carbonate + Mycophenolate
Severity: Moderate
Calcium carbonate and Mycophenolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids containing cations may reduce mycophenolate exposure. Mycophenolate mofetil absorption is also lowered when gastric pH is raised, so immunosuppression could be weaker.
What this interaction means in plain words
Calcium carbonate and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Higher gastric pH and cation binding reduce absorption of mycophenolate, particularly the mofetil formulation.
What to do
Separate calcium carbonate from mycophenolate by at least 2 hours. Watch for signs of rejection or reduced efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Mycophenolate?
MediHelp rates the interaction as moderate. Calcium carbonate and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids containing cations may reduce mycophenolate exposure. Mycophenolate mofetil absorption is also lowered when gastric pH is raised, so immunosuppression could be weaker.
How serious is the interaction between Calcium carbonate and Mycophenolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate calcium carbonate from mycophenolate by at least 2 hours. Watch for signs of rejection or reduced efficacy.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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