Drug interactions
Calcium carbonate + Sofosbuvir / velpatasvir
Severity: Moderate
Calcium carbonate and Sofosbuvir / velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir dissolves poorly at higher gastric pH. Antacids may reduce its absorption and could compromise hepatitis C cure rates.
What this interaction means in plain words
Calcium carbonate and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antacid-induced rise in gastric pH decreases velpatasvir solubility and absorption.
What to do
Separate sofosbuvir/velpatasvir and calcium carbonate by at least 4 hours.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as moderate. Calcium carbonate and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir dissolves poorly at higher gastric pH. Antacids may reduce its absorption and could compromise hepatitis C cure rates.
How serious is the interaction between Calcium carbonate and Sofosbuvir / velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate sofosbuvir/velpatasvir and calcium carbonate by at least 4 hours.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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