Drug interactions
Calcium carbonate + Sulfasalazine
Severity: Minor
Calcium carbonate and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Urinary alkalinization from calcium carbonate may increase excretion of the salicylate component of sulfasalazine metabolism. Any effect is small, and the clinical impact is generally negligible.
What this interaction means in plain words
Calcium carbonate and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Higher urinary pH ionizes salicylate-type metabolites, reducing tubular reabsorption.
What to do
No specific action is needed; assess clinical response to sulfasalazine if high-dose antacids are used regularly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Sulfasalazine?
MediHelp rates the interaction as minor. Calcium carbonate and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Urinary alkalinization from calcium carbonate may increase excretion of the salicylate component of sulfasalazine metabolism. Any effect is small, and the clinical impact is generally negligible.
How serious is the interaction between Calcium carbonate and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed; assess clinical response to sulfasalazine if high-dose antacids are used regularly.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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