Drug interactions
Calcium chloride + Gemifloxacin
Severity: Moderate
Calcium chloride and Gemifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral calcium chloride can bind gemifloxacin in the gut, reducing its absorption and potentially causing subtherapeutic antibiotic levels. The concern applies to oral calcium only.
What this interaction means in plain words
Calcium chloride and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of gemifloxacin by calcium cations in the gut lumen.
What to do
Separate oral gemifloxacin from oral calcium by at least 2 hours before or 3 hours after the calcium dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Calcium chloride with Gemifloxacin?
MediHelp rates the interaction as moderate. Calcium chloride and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral calcium chloride can bind gemifloxacin in the gut, reducing its absorption and potentially causing subtherapeutic antibiotic levels. The concern applies to oral calcium only.
How serious is the interaction between Calcium chloride and Gemifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate oral gemifloxacin from oral calcium by at least 2 hours before or 3 hours after the calcium dose.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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